City's record goalscorer has not found the net in any of his 10 career appearances at Anfield – including two when a late substitute for former club Atletico Madrid.
The Reds certainly won't be dropping their guard against the little Argentine.
Van Dijk said: “I think Aguero is one of the best strikers in the League – and he's been doing it for many years. It's a tough challenge and we will all have to be at our best to keep him quiet.
“He won't be worrying about not scoring at Anfield. He has enough experience not to think about those statistics.
“It will be a good challenge. City are the champions, with quality throughout the whole pitch, a clear plan, a fantastic manager, fantastic players – and are very difficult to beat."