With Alisson in goals and van Dijk leading the defence, Liverpool have been able to win the Champions League and Premier League over the past two seasons.
Speaking to the Liverpool Echo, Reds skipper Henderson said: "Virgil is a huge player for us. Everyone knows that. He's made such a big difference since he's been at the club.
"As a player, as a person, as a leader, everything. I haven't got enough words to describe him. He gives the team confidence and he just gets better and better. A real leader. He is the best centre-half in the world."
On Alisson, Henderson added: "Where do I start?! Ali is the best goalkeeper in the world. I know it is easy for me to say as I play with him but in the big moments, the saves he's made, his distribution, everything about him is world class.
"He is so laid back off the pitch, so chilled, a brilliant person to have around the dressing room. I couldn't speak highly enough of him really. A top-class keeper and he's made a real difference since he's been at the club."