Low, 61, announced on Tuesday that he will step down as manager of Die Mannschaft after this summer's delayed Euros following a 15-year spell in charge.
Reports had claimed that Klopp was the early favourite to leave Anfield and return to manage the national team of his native country.
But Klopp said today: "If you're asking am I available for the job of the German national team in the summer, no.
"Joachim Low did an incredible job, he is one of the best servants. I understand why he wants this as a European highlight, to squeeze the best he can from the tournament.
"I'm sure the German FA will find the best solution with the incredible players they have. I will not be available as a potential coach for the German team.
"I have three years left at Liverpool don't I? It's simple. You sign a contract and you stick to that."