With Liverpool 2-0 up against Atletico Madrid on the night and leading on aggregate, Adrian inadvertently allowed Atleti back into the game when his dreadful clearance was pounced on and Marcos Llorente fired home to level the tie.
"If you lose, you lose for some reason," said the Reds manager.
"The first goal is pretty obvious, but come on, Adrian has saved us so many times since he's here.
"He makes the wrong decision, that's clear, but that's how football is and nothing to blame."
While Adrian's howler allowed Atletico to level the tie, Klopp pointed out that it wasn't the moment the game was lost, and acknowledged that Liverpool had plenty of chances to win the tie.
"We will not blame him for a second," Klopp added. "He saved us in so many moments. This was not a moment we lost the game but it had a big impact.
"We conceded more goals after that and we didn't score the goals we needed.
"He's a grown man and he will deal with that."