Liverpool are four points outside the Champions League qualification places and Klopp says his side must win "more than 100%" at Old Trafford on Sunday.
“Whatever situation you are in, when you are a Liverpool player or manager, this is the game" said Klopp.
"It's the best place to go after watching them score five in one half. A lot of things can happen, we just need to make sure we are ready for it."
Asked if his side have to win, Klopp said: "More than 100%.
"Without winning games we have no chance of having European football. It will be a tough game, intense.
"We saw Man Utd last night and they are good, especially when you let them play.
"They were flying. I am pretty sure United still feel they have a chance [for the title]. Both teams have to win it which is a good recipe for the game."