Henderson has been out of action since February with a foot injury.
But Klopp appears confident that the 27-year-old will be fit and ready for the new campaign.
When asked if he'll be playing at Prenton Park tonight, Klopp said: “Yes… nobody has told me anything else!
“I think he always played when he was fit.
“So unless the medical department comes to me and tells me to rest him a little bit [he might not play] but they first would have to explain this to Hendo… and if they pass him and he accepts this, they will come to me!
“I think nothing could avoid this – he is looking forward to it, I am looking forward to it and I expect him in the line-up."