The first-leg of the quarterfinal will be held in London on Thursday.
Lippi said, “Arsenal are a strong and well-organised team. Napoli must play the way we know they are capable of, with all the wisdom and experience that they can count on with a Coach like Carlo Ancelotti and great players.
“For some, it's not an advantage and can be irrelevant, but I believe that playing the game at home with the possibility of extra time to be better.
"Especially in a stadium like the San Paolo."
He added: “When you have no hope of finishing first and are more or less guaranteed a spot in the top four, it is logical that you concentrate on the only competition you have left."