Saturday's game sees Puel come up against his former club, who are currently third from bottom of the table.
Puel has seen improvement at Southampton since Ralph Hasenhuttl took over as manager and he expects Saints to pull clear of relegation trouble.
"Of course they will," said Puel. "They have good ingredients and quality in the team. They have good organisation and mentality and had a good result against Chelsea. They had a good attitude in their last game also and they can continue that way.
"It will be a tough game as they are in form."