The Nigerian striker has only been included in the first-team squad for one match this season.
Musa arrived from CSKA Moscow in the summer of 2016 for a then-record fee of £16.6 million. He scored just two Premier League goals from 21 outings in his debut season.
"We will see," replied Puel when asked if Musa could be sold in January.
"Perhaps it is a possibility. We will see for the player and with the opportunity for the club also.
"There is always discussion and I need to have some discussions about some players."