The Argentine coach has always been outspoken about his dislike for the financial and corporate aspects in the modern game.
He is particularly upset about the number of games that players have to play in for both club and country, as his side prepare to take on Crystal Palace at home on Tuesday.
"What is clear is the calendar is so overcharged, it doesn't bear in mind the development or preparation," said the Leeds head coach.
"That's why I have serious doubts over the future of professional football because it is constantly commercialized, and the product is worse.
"It's based on selling more games, but it ignores whether teams are in better conditions to offer better results.
"I use the terms that the football industry uses, but it's difficult for me to think it in those terms.
"That's why I say it doesn't make sense to want to multiply the commercialization of a product when the product is only getting worse."