Lazio coach Simone Inzaghi recognises their derby with Roma could be decisive in the top four race.
Lazio are in third place and Roma in fourth, but a win today would open up the gap to 10 points.
Inzaghi said, “It would be three very important points, but there are 19 Finals from here to the end of the season.
"We won't settle for a draw, because the derby must always be played to win. Roma are doing very well and Paulo Fonseca has been able to maintain a competitive squad despite the many injuries.
“We have no fear of anyone, but only respect for Roma. Lazio are a more confident team than we were back on August 30, too."