Robbie Kruse and Son Heung-min started for Bayer Leverkusen on Sunday but were unable to guide the club to another victory.
A week after upsetting Borussia Dortmund 1-0 in the Bundesliga, die Werkself crashed 1-0 to Eintracht Frankfurt to fall seven points behind league leaders Bayern Munich.
Australian international Kruse operated on the right wing for 67 minutes before being replaced by Jan Hegeler while South Korean ace Son played a full 90 minutes on the left wing.
For Kruse, it was just his third start of the campaign as a lethargic Leverkusen compounded to Marco Russ' second-half header for their third defeat of the term thus far and their first at home in the league since March.
