The club are yet to score a goal in any of the six Premier League games Remy has missed through injury and suspension this season.
Krul told The Journal: "He's a world-class striker and it's the same for every team.
"If you're missing a world-class striker like Loic it's going to hurt you and on Saturday missing (Mathieu) Debuchy also did. I'm not saying we don't have the quality to replace them but you do miss that extra bit of quality."
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