The Reds have already secured top spot in Group B after winning all five of their group stage matches.
"We have to rotate, we will rotate. We have to rotate, that is the headline," he said.
"The medical department would smash me if I played the same side again, so I will make changes.
"I'm in the hands of the medical dept. I have to accept their decisions."
Asked if Mohamed Salah will start, Klopp added: "I cannot change all the line-up.
"We need players on the pitch so I can't rotate and start with nine, that's not possible.
"We will see if Mo plays or not and if he plays or scores or not, but the players are very understanding about the situation. We want to field the best possible side for the situation we are in."
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