Deep into stoppages, La Joya nutmegged one player, held off another and steered his finish into the far top corner from 10 yards.
“For my confidence, it's a very important goal, so I can keep working and improve over the next few months and help my teammates," Dybala told Sky Sport Italia.
“This goal gives us a big result against a Lazio side that plays very good football. It will help us a lot."
He added: “It wasn't the most beautiful match on a technical level and if it had ended 0-0, nobody would've complained."