Ronaldo left Juve after three seasons for Manchester United in final days of the summer market.
Chiellini told L'Equipe: "Is it difficult to turn the page? We have to find other balances, but in football we don't have a lot of time. You play every three days, then you go to the national team, so during the ten-day breaks the players are not there.
"You have little time to work but you have to come to an amalgamation. When you lose a champion like Cristiano ... It has happened to us before, I think of Pirlo, Buffon, we cannot replace them but the team finds a way to fill this absence with other players who have different characteristics."
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