"Mandzukic is not training with us, in agreement with the club," the Juve head coach told a news conference on Friday.
"If the agreement changes, I am open to everything."
Sporting director Fabio Paratici confirmed talks with Mandzukic over his future this week.
"With Mandzukic, we chose a quiet time for him to leave but a move to Qatar [in the summer] did not materialise so he stayed with us," Paratici said.
"Now we will talk to him and see what happens in January. We are evaluating, he is also evaluating. We need maximum calm, he is a great player.
"It has been an added value in recent years, we must thank him. If he considers it appropriate to leave, we will satisfy him, otherwise he will consider other solutions."