Juve have conceded 10 goals in five rounds - not counting their 3-3 Europa League result with Lech Poznan - while City let in just two in six games.
"These are statistics that can be overturned, but it will be an entertaining clash," said Del Neri.
"We are facing an important side in English and European football, so we hope to do well."
"I take it one game at a time. Tomorrow we are facing a very strong side that was built to win.
"It is going to be an important test to verify our progress and see if we have achieved the right maturity.