Fernandes, a £46.6million signing from Sporting Lisbon, made his United debut in a 0-0 draw at home to Wolves at Old Trafford.
United winger James, 22, saw enough in that game to believe he can develop an effective understanding with Fernandes for the Reds.
“He's settling in great," said James. “I know quite a few of the boys speak his language and he speaks great English as well.
“So I think as soon as he came in, he put his stamp on the game and he showed what he's about in that last game, on his debut.
“He was great, with the balls he played in behind and, for me, if we can get that bond, especially playing it in behind, I think that will be great."