The former boss of the England Women's National Team will now be the head of the MLS club.
The 43-year-old is the second ever manager at the newly minted club, after Diego Alonso departed.
Neville told the club's website: “I am incredibly delighted for this opportunity to coach Inter Miami and to work with Chris and the entire ownership group.
“This is a very young club with a lot of promise and upside, and I am committed to challenging myself, my players and everyone around me to grow and build a competitive soccer culture we can all be proud of.
“This fantastic soccer-loving market deserves consistent performances and a winning mentality, and I look forward to getting to work."