Southampton are, two points from safety and travel to Arsenal following a 3-0 defeat at fellow strugglers West Ham last week.
"I expect a reaction from the team," boss Mark Hughes said.
"We need to be more resilient when momentum goes against us. I've told them this week what is acceptable in games and what isn't."
Saints are without a win in their last five games and the former Stoke boss said: "We've got to go there and get a positive result.
"The bare minimum is a good performance for the travelling fans and to be positive in our outlook."