The star striker was forced off in the 10th minute of today's FA Cup win over Millwall with what appears to be a fairly serious ankle injury.
Son Heung-min stepped up and fired home a hat-trick as Spurs saw off their League One opponents 6-0 at White Hart Lane which is the type of performance required if the team wants to continue winning while Kane is sidelined.
"When you lose a player like Harry Kane, you miss him," said Pochettino.
"But it's important for the players in his position, like today Son or Vincent, to feel the net, score goals. We talked in the past about the squad. Now they are important.
"Harry Kane is our main striker, one of the best in England, but we cannot cry, we need to try to be positive. We have enough players to try to replace him and win games. It won't be an excuse if we don't win games or achieve our aims because Kane isn't in the team.
"It's about the team performance with different names. We need to try to win every game and I have to select 11 players every game. I'm very happy with Son. He can play like a striker. One of our best performances was against Manchester City and he was the striker when Harry was injured.
"I think we have different possibilities, to play different formations.
"Of course I'm disappointed by Harry's injury but now we have to find solutions and see which is the best player to replace him."