City have already qualified for the round of 16.
Guardiola said, "We go there to get first place in the group stage. The important thing is done - to qualify - but we go to maintain our rhythm.
"The Premier League is the main priority in general terms. We have 19 players in the first team fit and all of them travel. They are a really difficult opponent and we need the best players possible.
"Some players are going to play who didn't play the previous game.
"There are a lot of games but I don't want them to feel this is rotation. Every game is played with the best players for the circumstances for a specific game."