Arsenal must overcome a 2-0 deficit tonight in Germany to make Champions League progress.
Guardiola feels the German playmaker can continue to grow in his new environment following a £42.5million switch from Real Madrid on deadline day in September 2013.
"I never played in England, or trained a team (there), so I don't know how difficult (it is), but I can imagine how difficult it is (for Ozil) to play every three games in November, December, January," Guardiola said.
"But this is one game, it is a final, Arsenal know that, Ozil knows that.
"For one game, the player puts in everything.
"From my experience, I expect the performance from the opponents. Ozil will give the best performance and we have to be prepared."
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