The Reds travel to Serbia for their reverse fixture after beating Red Star 4-0 at Anfield two weeks ago.
Grujic, currently on loan with Hertha BSC, came through the ranks at Red Star before joining Liverpool in 2016. And speaking before tonight's clash, the midfielder warned his teammates that the fixture won't be easy.
"The two away games, yes they were outplayed, but to draw 0-0 with Napoli is a good achievement. They are really good defensively, especially around their box, and especially in the Marakana they seem to be able to find a bit extra, maybe from the supporters and the atmosphere. I am not expecting a lot of goals this time."