40-year old Wetherall has left his role as youth team manager at Valley Road and will now oversee the world's largest young player development program which includes more than 8,500 players aged between eight and 18.
The Football League's chief operating Officer, Andy Williamson, is delighted to have Wetherall on board. He said: "David is a high calibre appointment. He has set standards for players and coaches to aspire to throughout his career. We are delighted that he has accepted this hugely important role.
"The Football League is rightly proud if its track record in youth development, not just in terms of developing young players but also giving them access to first team football at a young age.
"We look forward to David joining The League and enhancing our contribution to this crucial area of the domestic game."