The Gunners will need to beat the Greek side on Wednesday night with any scoreline other than 1-0 and 2-1 to qualify for the knockout stages of the competition.
"Of course this is an important competition for me personally and for the club," said Flamini.
"We have a good test to prove we have the quality to go through and continue our adventure. Everyone is focused and I will try to help my partners.
"We are experienced for the big games and I believe we can progress."