Kazim-Richards believes silencing Francesco Totti will be key to winning the tie.
"I've got the feeling it can be a special night, but playing against Roma isn't going to be easy," the 28-year-old London-born player stated.
"We came back from Rome with a good result.
"Some of our players were not available, but we played a good game on Sunday [winning 3-2 against Excelsior] and we'll keep following the directives of our Coach.
"This game is important for everyone, and for the club as a whole.
"As for [Roma captain Francesco] Totti, he's a legend. He is a constant threat, but we have players capable of containing him."