Welbeck, 20, was booed by the massive African support as he made his senior England debut in Tuesday's friendly at Wembley.
Boateng followed a similar path, opting for Holland despite being born in Ghana.
Boateng, now at Greek club Skoda Xanthi, told the Mirror: "Danny has to take into consideration when he is making his decision that he has played in England all his life.
"I had nothing to do with Ghana when I was young, other than street football. It was when I went to Holland that I started to get a grounding in football professionally.
"I've never said that I regret the decision I made, because I don't. But looking back, because there were so many good players in the Dutch national team I had to sit on the bench and it was painful.
"I was hoping I would get a look-in but I didn't. Looking back I would have made a difference for Ghana. I would have gone to the World Cup and I would have played with great players such as Michael Essien and Asamoah Gyan.
"But I still think it's a perfectly understandable choice if Danny wants to play for England."