In October, world governing body Fifa said it wanted to expand the Club World Cup to 24 sides for 2021, plans opposed by its European counterpart Uefa.
Fifa has also held private discussions about a global Super League, which would see clubs stop playing in their own domestic leagues to take part.
"I struggle to see why an English team would need to leave," Ferguson said. "Without question, it is money orientated, but surely this would not be attractive to our clubs in the Premier League, which at the moment is the best domestic league in world football and is well supported financially by Sky, BT and now Amazon.
"Furthermore, the attraction of playing in the Champions League is huge for players, coaches and fans alike, as it remains the ultimate test in club football.
"A lot of clubs with great history could be lost if their partners in the Premier League upped sticks. I strongly believe this is a realistic appraisal of the value of domestic football."