Mascherano, the most-capped player in Argentina's history, made the announcement in a press conference at his current club, Estudiantes.
He said: "I want to announce that today I am retiring from soccer professionally.
"I want to thank this club that gave me the opportunity to finish my career in Argentina.
"I lived my profession 100%, to the maximum that I possibly can, and for a while now that has been getting harder.
"Sometimes you don't choose the end, it happens all by itself."
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