The Red Devils host Greek side Olympiakos in the round of 16 second leg at Old Trafford following their 2-0 loss in Piraeus, Athens last month.
United were easily beaten 3-0 by arch rivals Liverpool in the Premier League on Sunday which places a lot more impetus on the Olympiakos clash and Evra has urged the reigning English champions to turn the tide of negative results in order to change the morale of the players, coaching staff and the supporters.
"I think even a three-year-old United fan has been hurting by all the problems," Evra told reporters.
"But in life you always have a second chance and we get it tomorrow night.
"I'm not telling you we're going to qualify, but I can promise you we're all going to fight and respect the shirt and make sure all the fans will be really proud of us after the game.
"It's a difficult moment. It's a new challenge for us because we've never been in this situation. We're always used to playing to win the Premier League, to win games to win the Champions League.
"It's been a difficult season for everyone because we're not used to losing games. We always win.
"It's a tough moment and you have to show your character and personality. When you come out on the pitch and put on the United shirt, you know it's big story, a big pressure every year.
"This year is more difficult than a year ago, but I'm still confident. I think everyone wants to fight for this club. Everyone loves this club."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball