He told evertonfc.com: "The break won't affect our team spirit. We do have a number of players away at the minute so there is only a few of us who have stayed back here to train.
"Once everyone returns though the stories get told about what they have been up to and the camaraderie is back! It's as if we've never been away."
However, Osman does concede that the timing of the international break could have been better for David Moyes's side, who are on a six-game unbeaten run.
He adds: "When you get a run of form together like we have and you're scoring goals the break has possibly come at the wrong time.
"Having said that, we were short on players for the last game against Stoke. Injuries have been taking their toll and the amount of games we are playing mean it will be good to re-charge our batteries. That way we can get everyone back fit and raring to go again."