The German veteran is off contract in June and knows he won't be offered new terms by Juve.
"The Premier League would definitely appeal to me, that was never a secret, I always made it known openly," said the midfielder to ZDF.
"I'd be incredibly happy if I could join a Premier League club.
"There's talks. There is an exchange, but it also exists without a transfer."
Everton are regarded as the most likely destination for Khedira.