Th German club set up their advancement to the final eight with a 3-0 win in the first leg at the Westfalenstadion last week and further enhanced their status as favourites to clinch UEFA's second tier club title with a professional performance in North London, to move through 5-1on aggregate.
Pierre-Emerick Aubameyang did the damage for Dortmund with a brace either side of half-time to take his season tally to a remarkable 35 goals in all competitions.
The opener came in the 24th minute in some fashion when Spurs defenders sat off the Gabon international who swerved a near-unstoppable effort beyond Hugo Lloris from around 30 yards.
There were few problems for Thomas Tuchel's side who were able to put the tie beyond doubt with just under 20 minutes remaining with an efficient forward thrust.
Dortmund moved the ball quickly, with Henrikh Mkhitaryan feeding Aubameyang on the right side of the area, allowing the African Player of the Year to slot home despite the best efforts of Lloris.
Mauricio Pochettino's Spurs were able to pull one back a few moments later when Son Heun-ming pounced on a terrible backpass from Neven Subotic, rounded Roman Weidenfeller, and finished into an empty net but the damage had already been done.
Dortmund, who like Tottenham sit second on their respective league table, will now move into the quarter-finals of the Europa League where they have joined former manager Jurgen Klopp's Liverpool as well as holders Sevilla, Sparta Prague, Sporting Braga, Athletic Bilbao, Villarreal and Shakhtar Donetsk.
The draw for the elite eight will be made in Nyon, Switzerland on Friday afternoon.
2015/16 UEFA Europa League - Round of 16 second leg