The pair shone for victory at Cardiff City on Sunday.
“I think so," Defoe said on Sky Sports when asked if the win showed the two strikers can play together.
“Like I said before, at the end of the day you want to try and get your best players on the pitch.
“They're two great players to be fair. They're sharp, they make things happen, they score goals.
“Aubameyang's goal was brilliant, that Thierry Henry finish.
“Obviously we saw with Lacazette his movement, which I mentioned before hand, in and around the box really sharp, stays high, and we saw with the winning goal."