Spurs are currently locked in a battle for the league title with the Foxes. The North London club trail the East Midlands high-flyers by five points, with seven games left in the season.
Meanwhile, Sunderland are involved in a relegation battle and are in desperate need of points.
Former White Hart Lane ace Defoe told the club's official website: "Leicester are a great team. What they've done there this year is an unbelievable story.
"But I'd like to win that game - and then at the end of the season we're safe and Tottenham win the league."