City's 18-game Premier League winning run was ended by a goalless draw at Crystal Palace, who missed out on the chance to become the first team to beat them in the league this season when they had an injury-time penalty saved.
However it could still prove a costly afternoon for City with Gabriel Jesus leaving the field injured and in tears in the first half, and the league's top assist-maker Kevin de Bruyne stretchered off after a heavy tackle from Jason Puncheon in the final minute.
It leaves City with only one fit senior striker in Sergio Aguero who replaced Jesus at Selhurst Park.
Palace goalkeeper Wayne Hennessey told BT Sport: "We were unlucky, but it was a fantastic save at the end of the day. Luka [Milivojevic who took the penalty that was saved] has been fantastic for us with penalties this season, but it was a fantastic save.
"Manager Roy Hodgson has come in and has done a fantastic job and we all love him to bits and we hope he can stay for a long time. We have got the players in the dressing room to move forward and we hope we can move forward."
Crystal Palace defender Timothy Fosu-Mensah added: "It was a good game and we stayed compact and put pressure on. We were aggressive and gave them a good game. They have good players, the wingers are sharp and fast, and as a defender you have to stay focused for 90 minutes."