Crystal Palace midfielder Conor Gallagher has been called up into the senior England team for the first time as five players miss out on Monday's World Cup qualifier in San Marino.
Jack Grealish, Raheem Sterling, Luke Shaw, Jordan Henderson and Mason Mount will not travel.
Henderson and Grealish return to their clubs, Liverpool and Manchester City, for assessment on injuries.
City forward Sterling is unavailable due to a personal matter.
Chelsea midfielder Mount is recovering from dental surgery while Manchester United left-back Luke Shaw suffered a concussion.
Gallagher, on loan from Chelsea, will join up with Gareth Southgate's squad.