United have reportedly offered £25m for the 21-year-old right-back.
That is light years away from Palace's valuation, with the Independent claiming the Eagles want closer to £70m.
The Red Devils had been hoping that £40m would be the most they would need to secure the England U21 international.
Other interested clubs have been put off by Palace's demands.
Despite the setback, United are set to continue their pursuit of Wan-Bissaka.