Scudamore feels other leagues in Europe could be plotting to weaken the English top flight with measures such as quotas to prevent all the best players arriving.
"Another worry is European colleagues in other leagues getting jealous or envious," he said. "I'm sure the legislators and regulators in Europe would like to see us levelled down or dumbed down.
"We fight very hard in Europe to make sure legislators do not say 'they are too successful, what can we do to bring them down?'
"That's no recipe for progress. That is the thing I worry about more than anything else."
With the title race going to the wire and two English teams in the Champions League final, it has been seen as a time of celebration for the Premier League.
"Having two teams in the Champions League final is one measure," Scudamore said. "We measure a lot of things, a last-day decider is the most important thing for us. The relegation issues are not yet decided.
"Attendances are up again, we're going to be 5 per cent up, and now that measure is to do with what teams you lose or gain.
"It's a fantastic end to the season, last year was too. The truth is that it was unbelievable in many respects."