Michel Platini admits UEFA have" known for a long time" that match-fixing is a serious problem in football across Europe and Asia.
The sport's European governing body have asked police to examine 15 matches played this season after an early-warning system detected suspicious betting patterns.
UEFA president Platini and European Commission vice-president Franco Frattini have agreed to hold a conference next year to look at "criminal phenomena" in sport - such as money-laundering, match-fixing and illegal betting.
Platini told the Sunday Times: "It's a big problem for us. We have known that for a long time and it could become very bad for football, and for all sport, in the future.
"We know that in Hong Kong, Singapore and elsewhere in Asia you might have a single bet of 10 million dollars on a match ending 4-4.
"It's coming to the end of the match, it's 2-2 and there are four penalties, and it finishes 4-4.
"We knew about these cases because we do have an early-warning system in place. We do know that some teams were approached by people.
"These are 15 games we knew about because of the early-warning systems and because we knew, we were able to `protect' these games. But I am concerned and this is a big problem for the future, not only in Europe, but in Asia."
