On Thursday, England's 20 top flight clubs unanimously agreed to plans for sides to play one additional fixture each season starting in the 2010/11 campaign.
However, JFA vice-president Junji Ogura has been quick to voice his concerns about the possibility of the Premier League staging fixtures in Japan.
"It sounds problematic," said Ogura. "We are, in principle, opposed to having their (Premier League) games in Japan as we have to protect our league and clubs.
"In Japan, we don't allow anyone to play a match that involves only foreign clubs and no Japanese clubs.
"I don't think we will change our minds. You cannot have your matches outside your region without having an approval from the relevant confederation and national association.
"I don't know if the Asian Football Confederation (AFC) will give approval to the Premier League's overseas matches, but they may well oppose the Premier League's plans in order to protect their own associations.
"This issue can be brought to the table at the AFC Executive Committee meeting in March."