The club will be deducted 10 points which will all but guarantee their relegation from the SPL. All players will also be made available for transfer, although the club intends to ensure its remaining league fixtures are completed.
A club spokesperson confirmed: "In 2003 Brooks Mileson became owner of Gretna Football Club.
"His financing has enabled the club to achieve unprecedented success in Scottish football.
"However, due to his ill health, he is currently not in a position to facilitate further financing.
"Following a board meeting on Friday 7 March, the directors passed a resolution to place the club into administration, and the form al notice of intention was filed in the Court of Session in Edinburgh this morning.
"We anticipate that administrators will be appointed in the next few days."