The Premier League will trial the use of concussion substitutes from Saturday, 6 February.
The new rule means up to two permanent substitutions can be made in the event of head injuries, even if all replacements have already been used.
Opposition teams will also be able to make an additional "normal" substitution at a time of their choice.
It will run until the end of the 2020-21 season but can be extended into the 2021-22 campaign.
The trial will also be held in the Women's Super League and Women's Championship from the same date, and in the men's FA Cup from the fifth round on 9-11 February.