Their chances of a Europa League giant-killing against United have been rocked by the news that star striker Emmanuel Dennis will miss out through injury.
The Belgian side will also be without captain Ruud Vormer with both players not making the trip to Manchester.
All the odds are against Brugge in their second-leg despite heading to Old Trafford with a 1-1 draw.
Dennis, 22, was the scorer in Belgium after capitalising on Sergio Romero's horrendous error to put them ahead in the tie.
The Nigerian international has scored three times in Europe this season including a Champions League double against Real Madrid at the Bernabeu.
Midfielder Vormer has been an important figure this season having made 26 starts in the league.
Club Brugge are yet to taste victory on English soil having lost ten of their last 12 matches.