The winger has played seven times for the under-19s, but is now making the step up to a more senior setup.
He will play in the games against Poland and Germany.
Hudson-Odoi is joined in the squad by the likes of Aaron Wan-Bissaka, Phil Foden, James Maddison and Ryan Sessegnon.
Coach Aidy Boothroyd will be hoping for two positive results in the first international games for a few months.
Boothroyd said to reporters: "It's an exciting time.
"Getting the boys back together to put in some preparation for the Euros, and obviously two really good games this week against teams who could be our competitors in the summer.
"Both Poland and Germany will give us a really good test. Any team that qualifies for the U21 EURO Finals has to be respected, because it's no mean feat getting there.
"You can see from the standard of the countries that are heading to Italy in June, they're all top teams, so these will be difficult games."