Loftus-Cheek was part of Chelsea's Premier League title-winning squad in 2017, but admitted stepping into a European final will prove a whole new level.
"I've won the Premier League but it didn't feel the same because I hadn't had a big contribution to it," said Loftus-Cheek.
"But this season the Europa League is where I've had most of my game time.
"So it would feel amazing to be a main player in the team, with goals and assists, to then lift that trophy.
"I don't know what that feeling would be like as I've never done it. But it would be amazing.
"The final's going to be a tough one. Firstly it will just be amazing to be a part of a European final.
"It will be the biggest game of my career if I do play."