The Croatian only returned to training this week after recovering from a hamstring injury.
Speaking ahead of Wednesday's Champions League clash with Zenit St. Petersburg, manager Thomas Tuchel confirmed the news.
"He was in training yesterday and with a big smile and it was a pure pleasure to have him back," said Tuchel.
"But he tested positive today, for coronavirus, so he's quarantining for a few days.
"It's a huge setback for him personally and for all of us."
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