The Blues are in a difficult period in their season, as they are struggling for consistency in the Premier League.
However, with third place all but secure, Tuchel is attempting to motivate his side for their clash against Man United on Thursday.
He wants his players to ensure they do not lose at Old Trafford again, where they have not won since 2013.
"It's always a good time for a win,' said Tuchel, per the club's website.
"No matter if you won the last match or the last two against the same opponent, the best time for a win is always the next match.
"It just shows that it's not easy and these kind of streaks exist in football, that against some opponents it's a bit harder to get victories. Obviously Man Utd is that kind of opponent for us but with all due respect that we have for the history and for the occasion and for the quality in general at Man U, we will try to win and we will arrive to win and we will prepare to win this match.
"Then we will see what questions are asked and what the game demands and how the momentum in the game shifts or not. It's not so much like now or never, because now they are struggling with results recently. We honestly prepare all the time to have the feeling now or never, in every single match."
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